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What is the best treatment for kidney stones? Image result for Kidney Stone Treatment Percutaneous Lithotripsy (PCNL) is the best treatment for large stones in the kidney. General anesthesia is needed to do a PCNL. What are 3 treatments for kidney stones? Image result for Kidney Stone Treatment If you've been diagnosed with kidney stones (urolithiasis), you may have several options for treatment. These include medical therapy, extracorporeal shock wave lithotripsy (ESWL), percutaneous nephrolithotripsy (PCNL), and ureteroscopy